Kidney damage associated with aggressive blood pressure treatments
Aggressive combination treatments for high blood pressure that are intended to protect the kidneys may actually be damaging the organs, new research from the University of Virginia School of Medicine, United States (U.S.) suggests. Researchers identified the potential problem while studying strange kidney lesions in mice that cannot make the enzyme renin. Such lesions are also seen in patients with high blood pressure. The researchers determined the lesions are the work of renin cells, which are sometimes targeted in treating high blood pressure. “To treat hypertension, people use inhibitors of the renin angiotensin system,” explained R. Ariel Gomez, MD, director of UVA’s Child Health Research Center. “They’ve been in use for quite a bit now, and, for the most part, they’re safe. Our work in mice indicates that complete lack of renin results in vascular lesions. The question is whether aggressive, long-term use of compounds that completely ablate the renin angiote